PMS Formulas

ESTROGENEX – A NATURAL AROMATASE INHIBITOR AND ESTROGEN BLOCKERESTROGENEX – is a nutritional supplement, available without a prescription, designed tonormalize all hormone levels, yielding a wide spectrum of health and anti-aging benefits.ESTROGENEX – is a multi-pathway formulation that minimizes or eliminates the undesirableeffects associated with an estrogen dominant environment.ESTROGENEX – maintains the correct testosterone to estrogen ratios that yield the benefitsassociated with normal estrogen levels.ESTROGENEX – acts as an irreversible anti-aromatase agent and is thus a powerful elevator oftotal testosterone and maximum liberator of free testosterone.ESTROGENEX – may also play a role in long-term selective estrogen blocking and/or inhibition ofselective estrogen signaling.ESTROGENEX – may contribute to notable improvements in muscular growth and fat loss, inaddition to its wide array of health and anti-aging benefits.ESTROGENEX – is designed for: Normalization of all hormone levels, with specific tendenciestoward testosterone dominance, in all aging males.Prevention and reversal of Gynecomastia.Adjunctive supplementation for men undergoing hormone replacement therapy to ensure thatraising testosterone levels will not yield an undesirable increase in estrogen levels.A natural, more effective alternative for traditional testosterone hormone replacementtherapy.Bodybuilders and athletes during and immediately after periods of anabolic steroid use for thepurpose of stimulating endogenous testosterone production.Testosterone: Free-Testosterone and Plasma Protein-Bound TestosteroneTestosterone exists in the blood in either an active (free) or unbound state (+-2%) or inactivestate bound to one of two proteins: sex-hormone-binding-globulin (SHBG) (+-45%) or albumin(+-53%). Only when testosterone is in its free state can it directly interact with cellularreceptors and exert its activity. SHBG preferentially binds to testosterone over estrogen.Higher levels of SHBG in women help to maintain higher estrogen to testosterone ratios.Increased estrogen leads to an increase in SHBG. Thus, lowering the level of SHBG allows for anincreased level of free testosterone. Obviously, if testosterone finds it more difficult tolocate available plasma proteins in the presence of the additional compound, more will be leftin an unbound state.The amount of free testosterone can be altered (increased) by the use of aromatase inhibitors(the less testosterone that is synthesized [aromatized] into estrogen, the more totaltestosterone) or inhibitors of the plasma proteins that bind into testosterone. Manipulatingthe tendency of a testosterone to exist in an unbound state is an effective way to alter theoverall activity and potency of one?s overall testosterone levels. Higher levels oftestosterone produce an enhanced anti-glucocorticoid effect, which yields an anti-catabolic, ormore precisely, anti-proteoolytic, effect on muscle cells. This indirect anabolic effect is theresult of testosterone?s high affinity for binding with glucocorticoid receptors, thus blockingthe normal messenger pathway that triggers protein release from muscle tissue. More freetestosterone also likely results in higher concentrations of IGF-1 and IGF-1 receptor sites inskeletal muscle tissue. Correspondingly, lower testosterone also likely yields less IGF-1production and a corresponding decrease in IGF-1 receptor sites. Lower free testosterone alsolikely means a weaker immune system.The Synthesis (Aromatization) of Testosterone to Estrogen in Males and the Significance ofMaintaining Correct Testosterone to Estrogen Ratios.Although testosterone is considered to be a male hormone and estrogen a female hormone, bothhormones exist in both males and females and serve important functions for both. Estrogen is aterm that really represents a collection of female hormones, with esterone predominating. Sinceesterone is the estrogen that is normally in the highest concentration, it is an excellentmarker for basic estrogen levels for that reason. At least three estrogens have multiple andoverlapping functions. Men obtain their estrogen through the action of the aromatase, whichsynthesizes (aromatizes) testosterone into estrogen. However, when concentrations of estrogenbecome too high and/or the normal ratio of testosterone to estrogen decreases, the potentialfor the development of undesirable conditions arises. This includes the development of thefemale breast tissue (gynecomastia), increased body fat and water retention. Also, researchsuggests that DHT and prostate tissue growth have a direct connection to above normal estrogenelevations and reduced testosterone levels.The ESTROGENEX – Mechanism of ActionThe ESTROGENEX – proprietary formula was developed by combining naturally occurring aromataseinhibitors and inhibitors of the action of SHBG. The primary active ingredients in ESTROGENEXare Coumesterol and Chrysin. ESTROGENEX does not exert its action through any direct hormonalor prohormonal activity (androgenic or estrogenic).Before ESTROGENEX , little success had been achieved using chrysin as an effective aromataseinhibitor because chrysin is poorly absorbed in the bloodstream. However, in addition to theirown specific aromatase inhibiting and estrogen blocking actions, the proprietary blend of otheringredients work in synergy with chrysin to maintain a stable estrogen environment. We alsoincorporated our proprietary delivery system called EXTEND-RX? to avoid competing with otherhormones such as testosterone in the Aromatase Cytochrome P450.It is believed that ESTROGENEX exerts its effects through several mechanisms of action, whichcan be classified into two groups: 1. as an inhibitor of the aromatase enzyme responsible forthe conversion of testosterone to estrogen and an inhibitor of the action of SHBG, and 2. as ablocker of selective anabolic estrogen receptors and/or inhibitor of selective estrogensignaling.Substances that are aromatase inhibitors block the action of the enzyme aromatase that convertstestosterone to estrogen. Substances that act as an anti-estrogen are those that block theestrogen receptor. Thus, even though there is estrogen circulating in the blood, the estrogencannot exert its effects because it is blocked from attaching to its estrogen receptor. Thedietary supplement ESTROGENEX ? is a multi-pathway agent that exerts its influence by blockingvarious stages in the aromatase process and by inhibiting SHBG’s action; an activity notclearly addressed by any of the aromatase inhibiting or anti-estrogen products. Further, itappears that use of ESTROGENEX may result in long-term blocking of selective anabolic estrogenreceptors and/or inhibition of selective estrogen signaling (these anabolic estrogens are thosedemonstrating the undesirable effects associated with breast cancer and gynecomastia). Thisactivity has not been addressed by any known dietary supplements or pharmacological agents.ESTROGENEX as an Elevator of Total Testosterone and Liberator of Free TestosteroneAs a powerful aromatase inhibitor, ESTROGENEX also possesses notable testosterone stimulatingproperties. The aromatase inhibiting action reduces the signal that estrogen sends to the brainto suppress endogenous testosterone production (estrogen is a main feedback signal to controlthe release of testosterone, thus increasing the testicular output of testosterone). ESTROGENEXthus assists in resetting the body’s level of its own natural testosterone production byregulating the activity of the hypothalamic-pituitary-testicular axis (HPTA), which constantlyadjusts the body’s production of testosterone to maintain target blood levels. Continued use ofESTROGENEX results in not only a significant reduction in the production of estrogen, but alsoa corresponding substantial increase in endogenous testosterone.Only ESTROGENEX addresses all possible channels to estrogen maintenance and free testosteroneelevation, which means optimal hormonal levels for muscle building, fat loss and anti-agingsupport.

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Hi Tech Pharmaceuticals Estrogenex – 90 tab